Thermodilution-derived coronary absolute flow and resistance in patients with different INOCA endotypes

Abstract Background Thermodilution-derived measurement of absolute coronary flow and resistance has been recently validated by using a dedicated microcatheter pressure-temperature guidewire. Coronary (AbsF) derived (AbsR) can give precious information about the microcirculation in patients with ischemia non-obstructive artery disease (INOCA). The correlation different INOCA endotypes so far poorly investigated. Methods 108 underwent complete evaluation function testing, including acetylcholine (ACH) provocation adenosine testing (CFR/IMR) functional assessment left anterior descending thermodilution-derived AbsF AbsR. Results Among patients, 64% showed microvascular dysfunction (CMD) positive ACH reaction (ACH+) and/or abnormal CFR/IMR (CFR/IMR+), whom 38% presenting an isolated structural component (CFR/IMR+) 62% vasospastic (ACH+). ACH+ epicardial angina was detected 28.2% patients. found significantly lower than ACH− (0.174±0.09 vs 0.2019±0.09, p=0.03). Similarly, trend higher AbsR values as compared to (612.5±226.5 524.5±171.2, p=0.07, Fig. 1A). without either or CMD (0.172±0.06 0.202±0.09, p=0.05) towards CMD. (609.3±208.8 557.7±193.1, p=0.08, 1B) did not differ only: (0.176±0.06 0.197±0.09, p=0.31) 589.8±183.0 565.2±190.2, p=0.27). A modest between AbsQ IMR (r: −0.2: p: 0.05, 2). Conclusion vasomotor is highly prevalent evaluation, provocative test should be performed. Continuous thermodilution safe easily implemented provide new insights high reproducibility. exact diagnostic prognostic value these measurements, their optimal cutoff, assessed future studies. Funding Acknowledgement Type funding sources: None.